STRINGSTRING
six2a six2a eya2 eya2 znrf2a znrf2a arhgef12a arhgef12a scn4aa scn4aa hoxc12a hoxc12a sox11b sox11b atp1a2a atp1a2a large2 large2 osr1 osr1 col6a4a col6a4a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
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[Homology]
Score
six2aSine oculis homeobox homolog 2.1. (288 aa)    
Predicted Functional Partners:
eya2
Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.
   
 
 0.828
znrf2a
Zinc and ring finger 2a.
      
 0.777
arhgef12a
Rho guanine nucleotide exchange factor (GEF) 12a.
      
 0.742
scn4aa
Sodium channel protein type 4 subunit alpha A; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.
   
  
 0.669
hoxc12a
Homeo box C12a.
      
 0.655
sox11b
Transcription factor SOX.
   
 
 0.597
atp1a2a
Sodium/potassium-transporting ATPase subunit alpha.
   
  
 0.596
large2
LARGE xylosyl- and glucuronyltransferase 2; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by [...]
      
 0.585
osr1
Protein odd-skipped-related 1; Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification. Belongs to the Odd C2H2-type zinc-finger protein family.
   
  
 0.565
col6a4a
Collagen, type VI, alpha 4a.
      
 0.563
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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