STRINGSTRING
ek1 ek1 efna5b efna5b efna2a efna2a efna3b efna3b efna1b efna1b efna1a efna1a efna3a efna3a efna2b efna2b ENSDARP00000152912 ENSDARP00000152912 efnb1 efnb1 efnb3b efnb3b
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
ek1Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (981 aa)    
Predicted Functional Partners:
efna5b
Ephrin-A5b; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor [...]
   
 
 0.887
efna2a
Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the epha2 receptor may play a role in bone remodeling thro [...]
   
 
 0.881
efna3b
Ephrin-A3b; Belongs to the ephrin family.
   
 
 0.879
efna1b
Ephrin A-L1; Belongs to the ephrin family.
   
 
 0.872
efna1a
Ephrin-A1a; Belongs to the ephrin family.
   
 
 0.852
efna3a
Ephrin-A3a; Belongs to the ephrin family.
   
 
 0.848
efna2b
Ephrin-A2b; Belongs to the ephrin family.
   
 
 0.846
ENSDARP00000152912
Si:dkey-246i14.3; Belongs to the ephrin family.
   
 
 0.801
efnb1
Ephrin-B1; Belongs to the ephrin family.
   
 
 0.762
efnb3b
Efnb3 protein; Belongs to the ephrin family.
   
 
 0.721
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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