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hdrA hdrA hdrC hdrC hdrB hdrB mvhA mvhA mvhG mvhG mvhD mvhD ADL59100.1 ADL59100.1 fdhB fdhB fwdA fwdA fdhA2 fdhA2 mcrA mcrA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hdrACoB-CoM heterodisulfide reductase iron-sulfur, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrA family. (659 aa)    
Predicted Functional Partners:
hdrC
CoB-CoM heterodisulfide reductase, subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 0.999
hdrB
CoB-CoM heterodisulfide reductase, subunit B; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B); Belongs to the HdrB family.
 
 0.999
mvhA
F420-non-reducing hydrogenase, subunit A; Part of a complex that provides reducing equivalents for heterodisulfide reductase.
 
 0.999
mvhG
F420-non-reducing hydrogenase, subunit G; Part of a complex that provides reducing equivalents for heterodisulfide reductase; Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
 
 0.999
mvhD
F420-non-reducing hydrogenase, subunit D; Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase.
 0.999
ADL59100.1
Methyl viologen-reducing hydrogenase, subunit D-related protein.
 0.999
fdhB
Formate dehydrogenase, beta subunit.
 
 0.997
fwdA
Tungsten formylmethanofuran dehydrogenase, subunit A.
   
 
 0.993
fdhA2
Formate dehydrogenase, alpha subunit.
  
 0.970
mcrA
Methyl-coenzyme M reductase I, subunit alpha; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. Neither N-6- mercaptohexanoylthreonine phosphate (H-S-HxoTP) nor N-8- mercaptooctanoylthreonine phosphate (H-SOcoTP) nor any other thiol compound such as CoA or CoM [...]
  
 
 0.956
Your Current Organism:
Methanothermobacter marburgensis
NCBI taxonomy Id: 79929
Other names: M. marburgensis str. Marburg, Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133), Methanobacterium thermoautotrophicum str. Marburg, Methanothermobacter marburgensis str. Marburg, Methanothermobacter marburgensis strain Marburg
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