node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Rv1603 | Rv1601 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC1 | Rv1603 | Rv1600 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Rv1600, (MTCY336.04c), len: 380 aa. Probable hisC1,histidinol-phosphate aminotransferase O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa), FASTA results: opt: 1353, E(): 0, (59.0% identity in 356 aa overlap). Some similarity to other Mycobacterium tuberculosis aminotransferases e.g. Rv3772|MTCY13D12.06,FASTA results: E(): 7.4e-25, (33.7% identity in 365 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases. Note that previously known as hisC. | 0.998 |
hisA | hisD | Rv1603 | Rv1599 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Probable histidinol dehydrogenase HisD (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisE | Rv1603 | Rv2122c | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP pyrophosphatase HisE; Rv2122c, (MTCY261.18), len: 93 aa. HisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see citation below), similar to many. Note that previously misnamed hisI. | 0.963 |
hisA | hisF | Rv1603 | Rv1605 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Probable cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | Rv1603 | Rv2121c | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.996 |
hisA | hisH | Rv1603 | Rv1602 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Probable amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisA | hisI | Rv1603 | Rv1606 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | impA | Rv1603 | Rv1604 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.997 |
hisA | trpC | Rv1603 | Rv1611 | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | Rv1611, (MTCY01B2.03), len: 272 aa. Probable trpC,indole-3-glycerol phosphate synthase. Similar to Q55508|SLR0546 hypothetical 33.0 kDa protein from synechocystis SP (295 aa), FASTA score: opt: 26, E(): 7.6e-32, (44.2% identity in 265 aa overlap); also similar to TRPC_AZOBR|P26938 ndole-3-glycerol-phosphate synthaseindole-3-glycerol-phosphate synthase from Azospirillum brasilense (262 aa), FASTA score: opt: 596,E(): 4.8e-30, (43.8% identity in 258 aa overlap). Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium leprae (272 aa) (90.8% identity in 272 aa overlap). Contains indole-3-gl [...] | 0.979 |
hisB | hisA | Rv1601 | Rv1603 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.999 |
hisB | hisC1 | Rv1601 | Rv1600 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Rv1600, (MTCY336.04c), len: 380 aa. Probable hisC1,histidinol-phosphate aminotransferase O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa), FASTA results: opt: 1353, E(): 0, (59.0% identity in 356 aa overlap). Some similarity to other Mycobacterium tuberculosis aminotransferases e.g. Rv3772|MTCY13D12.06,FASTA results: E(): 7.4e-25, (33.7% identity in 365 aa overlap). Contains aminotransferases class-II pyridoxal-phosphate attachment site (PS00599). Belongs to class-II of pyridoxal-phosphate-dependent aminotransferases. Note that previously known as hisC. | 0.999 |
hisB | hisD | Rv1601 | Rv1599 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable histidinol dehydrogenase HisD (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Rv1601 | Rv2122c | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosyl-AMP pyrophosphatase HisE; Rv2122c, (MTCY261.18), len: 93 aa. HisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see citation below), similar to many. Note that previously misnamed hisI. | 0.981 |
hisB | hisF | Rv1601 | Rv1605 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | Rv1601 | Rv2121c | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). | 0.994 |
hisB | hisH | Rv1601 | Rv1602 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisI | Rv1601 | Rv1606 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | impA | Rv1601 | Rv1604 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. | 0.973 |
hisB | trpC | Rv1601 | Rv1611 | Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E(): 0, (57.4% identity in 202 aa overlap). Belongs to the imidazoleglycerol-phosphate dehydratase family. | Rv1611, (MTCY01B2.03), len: 272 aa. Probable trpC,indole-3-glycerol phosphate synthase. Similar to Q55508|SLR0546 hypothetical 33.0 kDa protein from synechocystis SP (295 aa), FASTA score: opt: 26, E(): 7.6e-32, (44.2% identity in 265 aa overlap); also similar to TRPC_AZOBR|P26938 ndole-3-glycerol-phosphate synthaseindole-3-glycerol-phosphate synthase from Azospirillum brasilense (262 aa), FASTA score: opt: 596,E(): 4.8e-30, (43.8% identity in 258 aa overlap). Equivalent to AL0499 13|MLCB1610_24 from Mycobacterium leprae (272 aa) (90.8% identity in 272 aa overlap). Contains indole-3-gl [...] | 0.522 |