node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv0458 | adhC | Rv0458 | Rv3045 | Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuber [...] | Rv3045, (MTV012.60), len: 346 aa. Probable adhC,NADP-dependent alcohol dehydrogenase, equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982,E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c putative dehydrogenase from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA score [...] | 0.927 |
Rv0458 | adhD | Rv0458 | Rv3086 | Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuber [...] | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.630 |
Rv0458 | hsaG | Rv0458 | Rv3535c | Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuber [...] | Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.913 |
Rv3087 | adhD | Rv3087 | Rv3086 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.977 |
Rv3087 | fadD13 | Rv3087 | Rv3089 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | 0.989 |
Rv3087 | lipR | Rv3087 | Rv3084 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.976 |
Rv3087 | mymA | Rv3087 | Rv3083 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.987 |
Rv3087 | sadH | Rv3087 | Rv3085 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable short-chain type dehydrogenase/reductase; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.970 |
Rv3087 | tgs4 | Rv3087 | Rv3088 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA. | 0.988 |
adhC | Rv0458 | Rv3045 | Rv0458 | Rv3045, (MTV012.60), len: 346 aa. Probable adhC,NADP-dependent alcohol dehydrogenase, equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982,E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c putative dehydrogenase from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA score [...] | Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuber [...] | 0.927 |
adhC | adhD | Rv3045 | Rv3086 | Rv3045, (MTV012.60), len: 346 aa. Probable adhC,NADP-dependent alcohol dehydrogenase, equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982,E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c putative dehydrogenase from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA score [...] | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.553 |
adhD | Rv0458 | Rv3086 | Rv0458 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa), FASTA scores: opt: 2767, E(): 0, (79.7% identity in 507 aa overlap); AAC13641.1|AF029733 chloroacetaldehyde dehydrogenase from Xanthobacter autotrophicus (505 aa), FASTA scores: opt: 2563, E(): 0, (75.4% identity in 492 aa overlap); Q9RJZ6|DHAL_STRCO probable aldehyde dehydrogenase from Streptomyces coelicolor (507 aa). Also similar to other semialdehyde dehydrogenases in Mycobacterium tuber [...] | 0.630 |
adhD | Rv3087 | Rv3086 | Rv3087 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | 0.977 |
adhD | adhC | Rv3086 | Rv3045 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Rv3045, (MTV012.60), len: 346 aa. Probable adhC,NADP-dependent alcohol dehydrogenase, equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa), FASTA scores: opt: 1982,E(): 1.3e-111, (85.85% identity in 346 aa overlap); Q9AE96|ADHC from Mycobacterium smegmatis (348 aa), FASTA scores: opt: 1808, E(): 3.4e-101, (78.95% identity in 347 aa overlap); Q9EWF1|SCK13.33c putative dehydrogenase from Streptomyces coelicolor (346 aa), FASTA scores: opt: 1508,E(): 3.3e-83, (64.45% identity in 346 aa overlap); O06007|ADHA from Bacillus subtilis (349 aa), FASTA score [...] | 0.553 |
adhD | fadD13 | Rv3086 | Rv3089 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | 0.983 |
adhD | hsaG | Rv3086 | Rv3535c | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.552 |
adhD | lipR | Rv3086 | Rv3084 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.991 |
adhD | mymA | Rv3086 | Rv3083 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.982 |
adhD | nrdB | Rv3086 | Rv0233 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain); Probable oxidase that might be involved in lipid metabolism. | 0.730 |
adhD | sadH | Rv3086 | Rv3085 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable short-chain type dehydrogenase/reductase; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.991 |