STRINGSTRING
JMJD6 JMJD6 HIST1H4B HIST1H4B BRDT BRDT KDM8 KDM8 LIN9 LIN9 BRD3 BRD3 FAT1 FAT1 METTL23 METTL23 C5H14ORF169 C5H14ORF169 U2AF2 U2AF2 LOC769866 LOC769866
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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JMJD6Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (414 aa)    
Predicted Functional Partners:
HIST1H4B
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.790
BRDT
Bromodomain testis associated.
    
 
 0.742
KDM8
Lysine demethylase 8.
   
  
 0.737
LIN9
DIRP domain-containing protein.
      
 0.707
BRD3
Bromodomain containing 3.
    
 
 0.690
FAT1
FAT atypical cadherin 1.
   
  
 0.670
METTL23
Methyltransferase like 23.
      
 0.663
C5H14ORF169
Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethyla [...]
   
  
 0.631
U2AF2
U2 small nuclear RNA auxiliary factor 2.
    
 
 0.631
LOC769866
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
      
 0.630
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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