STRINGSTRING
TWIST2 TWIST2 ZEB2 ZEB2 ZEB1 ZEB1 SNAI2 SNAI2 SNAI1 SNAI1 CDH1 CDH1 EDAR EDAR PAX7 PAX7 CDH2 CDH2 MSX1 MSX1 EBF4 EBF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TWIST2Dermo protein. (160 aa)    
Predicted Functional Partners:
ZEB2
Smad-interacting protein 1.
   
  
 0.742
ZEB1
Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter (By similarity). Binds to delta 1-crystallin enhancer core and represses lens-specific transcription. It binds as well many other non-lens specific DNA sequences.
   
  
 0.738
SNAI2
Uncharacterized protein.
   
  
 0.689
SNAI1
Snail like protein.
   
  
 0.681
CDH1
Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.
      
 0.590
EDAR
Ectodysplasin A1 receptor.
      
 0.568
PAX7
PAX7 protein.
   
  
 0.468
CDH2
Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity).
   
  
 0.463
MSX1
Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death.
   
  
 0.459
EBF4
EBF family member 4.
      
 0.431
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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