STRINGSTRING
NPPC-2 NPPC-2 CNP1 CNP1 NPR2 NPR2 WDR45B WDR45B CENPC CENPC NPPA NPPA CENPI CENPI AVP AVP MAL2 MAL2 NMT1 NMT1 RAB40B RAB40B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NPPC-2C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (130 aa)    
Predicted Functional Partners:
CNP1
C-type natriuretic peptide 1.
     
 0.984
NPR2
Guanylate cyclase.
     
 0.932
WDR45B
WD repeat domain phosphoinositide-interacting protein 3; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. In the cellular response to starvation, may also function in the inhibition of the mTORC1 signaling pathway. Belongs to the WD repeat SVP1 family.
      
 0.749
CENPC
Uncharacterized protein.
      
 0.700
NPPA
Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).
      
 0.673
CENPI
Centromere protein I; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
      
 0.666
AVP
Vasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone.
   
  
 0.635
MAL2
MARVEL domain-containing protein.
      
 0.601
NMT1
Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.
      
 0.601
RAB40B
SOCS box domain-containing protein.
      
 0.580
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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