STRINGSTRING
DR1 DR1 DRAP1 DRAP1 POLE3 POLE3 TBP TBP TBPL2 TBPL2 BTAF1 BTAF1 TADA2A TADA2A YEATS2 YEATS2 KAT14 KAT14 SGF29 SGF29 TADA3 TADA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DR1Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). (176 aa)    
Predicted Functional Partners:
DRAP1
DR1 associated protein 1.
   
 0.997
POLE3
CBFD_NFYB_HMF domain-containing protein.
   
 
0.924
TBP
TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
   
 
 0.908
TBPL2
TATA box binding protein-like 2.
    
 
 0.905
BTAF1
B-TFIID TATA-box binding protein associated factor 1.
    
 
 0.900
TADA2A
Transcriptional adapter 2-alpha; Component of some complex with histone acetyltransferase activity. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity).
   
 0.876
YEATS2
YEATS domain containing 2.
    
 
 0.810
KAT14
N-acetyltransferase domain-containing protein.
    
 
 0.807
SGF29
SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me.
    
 0.802
TADA3
Transcriptional adaptor 3.
    
 0.795
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (10%) [HD]