node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH6 | H6PD | ENSGALP00000031485 | ENSGALP00000003917 | PKS_ER domain-containing protein. | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | 0.653 |
ADH6 | HAO1 | ENSGALP00000031485 | ENSGALP00000014358 | PKS_ER domain-containing protein. | FMN hydroxy acid dehydrogenase domain-containing protein. | 0.466 |
ADH6 | HAO2 | ENSGALP00000031485 | ENSGALP00000023770 | PKS_ER domain-containing protein. | Hydroxyacid oxidase 2. | 0.524 |
ADH6 | PGP | ENSGALP00000031485 | ENSGALP00000009453 | PKS_ER domain-containing protein. | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. | 0.539 |
DCUN1D1 | MTDH | ENSGALP00000014300 | ENSGALP00000055382 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. | Uncharacterized protein. | 0.519 |
DCUN1D1 | MTDH-2 | ENSGALP00000014300 | ENSGALP00000052845 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. | Uncharacterized protein. | 0.536 |
DCUN1D1 | PGP | ENSGALP00000014300 | ENSGALP00000009453 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. | 0.708 |
DPYD | H6PD | ENSGALP00000065717 | ENSGALP00000003917 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | 0.478 |
DPYD | PGP | ENSGALP00000065717 | ENSGALP00000009453 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. | 0.527 |
GRHPR | H6PD | ENSGALP00000008696 | ENSGALP00000003917 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | 0.681 |
GRHPR | HAO1 | ENSGALP00000008696 | ENSGALP00000014358 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | FMN hydroxy acid dehydrogenase domain-containing protein. | 0.935 |
GRHPR | HAO2 | ENSGALP00000008696 | ENSGALP00000023770 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hydroxyacid oxidase 2. | 0.935 |
GRHPR | PGP | ENSGALP00000008696 | ENSGALP00000009453 | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. | 0.917 |
H6PD | ADH6 | ENSGALP00000003917 | ENSGALP00000031485 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | PKS_ER domain-containing protein. | 0.653 |
H6PD | DPYD | ENSGALP00000003917 | ENSGALP00000065717 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. | 0.478 |
H6PD | GRHPR | ENSGALP00000003917 | ENSGALP00000008696 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | Glyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.681 |
H6PD | HAO1 | ENSGALP00000003917 | ENSGALP00000014358 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | FMN hydroxy acid dehydrogenase domain-containing protein. | 0.688 |
H6PD | HAO2 | ENSGALP00000003917 | ENSGALP00000023770 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | Hydroxyacid oxidase 2. | 0.690 |
H6PD | PGP | ENSGALP00000003917 | ENSGALP00000009453 | Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP. | 0.510 |
HAO1 | ADH6 | ENSGALP00000014358 | ENSGALP00000031485 | FMN hydroxy acid dehydrogenase domain-containing protein. | PKS_ER domain-containing protein. | 0.466 |