STRINGSTRING
SEMA3D SEMA3D NRP1 NRP1 PLXNA1 PLXNA1 TBX18 TBX18 PLXND1 PLXND1 TCF21 TCF21 PLXNA4 PLXNA4 WT1 WT1 SCX SCX PLXNA2 PLXNA2 FAM136A FAM136A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SEMA3DSemaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (761 aa)    
Predicted Functional Partners:
NRP1
Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction (By similarity); Belongs t [...]
   
 
 0.861
PLXNA1
Plexin A1.
    
 
 0.839
TBX18
Uncharacterized protein.
      
 0.788
PLXND1
Plexin D1.
    
 
 0.782
TCF21
BHLH domain-containing protein.
      
 0.757
PLXNA4
Plexin A4.
    
 
 0.752
WT1
Uncharacterized protein.
      
 0.707
SCX
Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
      
 0.703
PLXNA2
Plexin A2.
   
 
 0.658
FAM136A
Uncharacterized protein.
      
 0.622
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (10%) [HD]