STRINGSTRING
BCL6 BCL6 BCOR BCOR CXCR5 CXCR5 IRF4 IRF4 ICOS ICOS AICDA AICDA BCORL1 BCORL1 CD4 CD4 PAX5 PAX5 CD40LG CD40LG CD40 CD40
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BCL6B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] (708 aa)    
Predicted Functional Partners:
BCOR
BCL6 corepressor.
    
 
 0.917
CXCR5
Chemokine receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.885
IRF4
Interferon regulatory factor 4.
   
 
 0.863
ICOS
IGv domain-containing protein.
      
 0.861
AICDA
CMP/dCMP-type deaminase domain-containing protein.
   
  
 0.854
BCORL1
BCL6 corepressor like 1.
    
 
 0.843
CD4
Uncharacterized protein.
   
  
 0.802
PAX5
Pax-5 protein.
      
 0.796
CD40LG
CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.
      
 0.780
CD40
Uncharacterized protein.
   
  
 0.771
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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