STRINGSTRING
ALPP ALPP ACP1 ACP1 ALPL ALPL GCH1 GCH1 TPK1 TPK1 NTPCR NTPCR PSAT1 PSAT1 AGXT AGXT NADK NADK TRIP11 TRIP11 GOT1 GOT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ALPPAlkaline phosphatase. (520 aa)    
Predicted Functional Partners:
ACP1
Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
    
 0.914
ALPL
Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family.
  
  
0.903
GCH1
GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence; Belongs to the GTP cyclohydrolase I family.
   
 
  0.900
TPK1
Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.
     
  0.900
NTPCR
Nucleoside-triphosphatase.
     
  0.900
PSAT1
Phosphoserine aminotransferase.
     
 0.852
AGXT
Alanine--glyoxylate and serine--pyruvate aminotransferase.
   
 
 0.843
NADK
Uncharacterized protein.
   
 
  0.828
TRIP11
Thyroid hormone receptor interactor 11.
   
 0.708
GOT1
Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]
      
 0.696
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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