node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALX1 | HMGA2 | ENSGALP00000041112 | ENSGALP00000016038 | ALX homeobox 1. | High mobility group protein I-C. | 0.545 |
DICER1 | HMGA2 | ENSGALP00000036777 | ENSGALP00000016038 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | High mobility group protein I-C. | 0.549 |
DICER1 | LIN28A | ENSGALP00000036777 | ENSGALP00000056558 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | 0.763 |
DICER1 | LIN28B | ENSGALP00000036777 | ENSGALP00000052382 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | Protein lin-28 homolog B; Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Belongs to the lin-28 family. | 0.699 |
HMGA2 | ALX1 | ENSGALP00000016038 | ENSGALP00000041112 | High mobility group protein I-C. | ALX homeobox 1. | 0.545 |
HMGA2 | DICER1 | ENSGALP00000016038 | ENSGALP00000036777 | High mobility group protein I-C. | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | 0.549 |
HMGA2 | IGF2BP2 | ENSGALP00000016038 | ENSGALP00000072320 | High mobility group protein I-C. | Insulin like growth factor 2 mRNA binding protein 2. | 0.836 |
HMGA2 | LCORL | ENSGALP00000016038 | ENSGALP00000028143 | High mobility group protein I-C. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. | 0.708 |
HMGA2 | LIN28A | ENSGALP00000016038 | ENSGALP00000056558 | High mobility group protein I-C. | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | 0.712 |
HMGA2 | LIN28B | ENSGALP00000016038 | ENSGALP00000052382 | High mobility group protein I-C. | Protein lin-28 homolog B; Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Belongs to the lin-28 family. | 0.748 |
HMGA2 | MSRB3 | ENSGALP00000016038 | ENSGALP00000065695 | High mobility group protein I-C. | Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. | 0.538 |
HMGA2 | NCAPG | ENSGALP00000016038 | ENSGALP00000051094 | High mobility group protein I-C. | Non-SMC condensin I complex subunit G. | 0.621 |
HMGA2 | SUOX | ENSGALP00000016038 | ENSGALP00000058284 | High mobility group protein I-C. | Sulfite oxidase. | 0.630 |
HMGA2 | ZFAT | ENSGALP00000016038 | ENSGALP00000073982 | High mobility group protein I-C. | Zinc finger and AT-hook domain containing. | 0.583 |
IGF2BP2 | HMGA2 | ENSGALP00000072320 | ENSGALP00000016038 | Insulin like growth factor 2 mRNA binding protein 2. | High mobility group protein I-C. | 0.836 |
IGF2BP2 | LIN28B | ENSGALP00000072320 | ENSGALP00000052382 | Insulin like growth factor 2 mRNA binding protein 2. | Protein lin-28 homolog B; Suppressor of specific microRNA (miRNA) biogenesis. Binds target primary miRNA transcripts and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. The specific interaction with target pri-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Belongs to the lin-28 family. | 0.610 |
LCORL | HMGA2 | ENSGALP00000028143 | ENSGALP00000016038 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. | High mobility group protein I-C. | 0.708 |
LCORL | NCAPG | ENSGALP00000028143 | ENSGALP00000051094 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. | Non-SMC condensin I complex subunit G. | 0.960 |
LCORL | ZFAT | ENSGALP00000028143 | ENSGALP00000073982 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. | Zinc finger and AT-hook domain containing. | 0.734 |
LIN28A | DICER1 | ENSGALP00000056558 | ENSGALP00000036777 | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization [...] | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] | 0.763 |