STRINGSTRING
MMACHC MMACHC MMADHC MMADHC MTR MTR C6orf58 C6orf58 MTRR MTRR DGKE DGKE AGBL3 AGBL3 MMUT MMUT MMAB MMAB MMAA MMAA LMBRD1 LMBRD1
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MMACHCMethylmalonic aciduria and homocystinuria type C protein homolog; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalami [...] (238 aa)    
Predicted Functional Partners:
MMADHC
Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC.
    
 0.888
MTR
Uncharacterized protein.
   
 0.856
C6orf58
Chromosome 6 open reading frame 58.
   
  
 0.844
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase.
   
 
 0.808
DGKE
Diacylglycerol kinase.
   
  
 0.706
AGBL3
ATP/GTP binding protein like 3.
      
 0.701
MMUT
Methylmalonyl-CoA mutase.
   
  
 0.684
MMAB
Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
     
 0.628
MMAA
Metabolism of cobalamin associated A.
      
 0.627
LMBRD1
Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity); Belongs to the LIMR family. LMBRD1 subfamily.
      
 0.626
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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