DIO1 protein (Gallus gallus) - STRING interaction network

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DIO1

Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). (229 aa)

Predicted Functional Partners:

SELENOP1

0.850

DIO2

0.822

MSRB1

0.742

SEPHS2L

0.741

SELENOF

0.707

SELENOW

0.707

TXNRD1

0.706

GPX4

0.702

GPX3

0.701

SELENOI

0.666

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DIO1	DIO2	ENSGALP00000017451	ENSGALP00000068702	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	0.822
DIO1	GPX3	ENSGALP00000017451	ENSGALP00000007185	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Uncharacterized protein.	0.701
DIO1	GPX4	ENSGALP00000017451	ENSGALP00000069197	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.702
DIO1	MSRB1	ENSGALP00000017451	ENSGALP00000008680	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	MsrB domain-containing protein.	0.742
DIO1	SELENOF	ENSGALP00000017451	ENSGALP00000051633	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Sep15_SelM domain-containing protein.	0.707
DIO1	SELENOI	ENSGALP00000017451	ENSGALP00000026672	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.666
DIO1	SELENOP1	ENSGALP00000017451	ENSGALP00000073407	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	SelP_N domain-containing protein.	0.850
DIO1	SELENOW	ENSGALP00000017451	ENSGALP00000067698	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Selenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity); Belongs to the SelWTH family. Selenoprotein W subfamily.	0.707
DIO1	SEPHS2L	ENSGALP00000017451	ENSGALP00000070567	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Uncharacterized protein.	0.741
DIO1	TXNRD1	ENSGALP00000017451	ENSGALP00000057732	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	Uncharacterized protein.	0.706
DIO2	DIO1	ENSGALP00000068702	ENSGALP00000017451	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).	0.822
DIO2	GPX3	ENSGALP00000068702	ENSGALP00000007185	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Uncharacterized protein.	0.742
DIO2	GPX4	ENSGALP00000068702	ENSGALP00000069197	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.601
DIO2	MSRB1	ENSGALP00000068702	ENSGALP00000008680	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	MsrB domain-containing protein.	0.788
DIO2	SELENOF	ENSGALP00000068702	ENSGALP00000051633	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Sep15_SelM domain-containing protein.	0.743
DIO2	SELENOI	ENSGALP00000068702	ENSGALP00000026672	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.604
DIO2	SELENOP1	ENSGALP00000068702	ENSGALP00000073407	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	SelP_N domain-containing protein.	0.533
DIO2	SELENOW	ENSGALP00000068702	ENSGALP00000067698	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Selenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity); Belongs to the SelWTH family. Selenoprotein W subfamily.	0.705
DIO2	SEPHS2L	ENSGALP00000068702	ENSGALP00000070567	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Uncharacterized protein.	0.608
DIO2	TXNRD1	ENSGALP00000068702	ENSGALP00000057732	Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.	Uncharacterized protein.	0.714

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