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WDR91 WDR91 WDR81 WDR81 MFSD12 MFSD12 CCZ1 CCZ1 BECN1 BECN1 WDR12 WDR12 EPG5 EPG5 NOP58 NOP58 PLEKHM1 PLEKHM1 ZFYVE27 ZFYVE27 CCDC93 CCDC93
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
WDR91WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (751 aa)    
Predicted Functional Partners:
WDR81
WD repeat domain 81.
   
 
 0.988
MFSD12
Major facilitator superfamily domain containing 12.
      
 0.783
CCZ1
Vacuolar fusion protein CCZ1 homolog.
      
 0.750
BECN1
Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.
    
 
 0.683
WDR12
Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
   
  
 0.675
EPG5
Uncharacterized protein.
      
 0.601
NOP58
NOP58 ribonucleoprotein.
      
 0.583
PLEKHM1
Uncharacterized protein.
      
 0.534
ZFYVE27
Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
   
  
 0.525
CCDC93
Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family.
      
 0.522
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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