node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BECN1 | CCZ1 | ENSGALP00000004697 | ENSGALP00000005469 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Vacuolar fusion protein CCZ1 homolog. | 0.414 |
BECN1 | EPG5 | ENSGALP00000004697 | ENSGALP00000056736 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Uncharacterized protein. | 0.410 |
BECN1 | PLEKHM1 | ENSGALP00000004697 | ENSGALP00000065696 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | Uncharacterized protein. | 0.417 |
BECN1 | WDR81 | ENSGALP00000004697 | ENSGALP00000053129 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | WD repeat domain 81. | 0.767 |
BECN1 | WDR91 | ENSGALP00000004697 | ENSGALP00000019133 | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.683 |
CCDC93 | WDR81 | ENSGALP00000019790 | ENSGALP00000053129 | Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. | WD repeat domain 81. | 0.411 |
CCDC93 | WDR91 | ENSGALP00000019790 | ENSGALP00000019133 | Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.522 |
CCZ1 | BECN1 | ENSGALP00000005469 | ENSGALP00000004697 | Vacuolar fusion protein CCZ1 homolog. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.414 |
CCZ1 | PLEKHM1 | ENSGALP00000005469 | ENSGALP00000065696 | Vacuolar fusion protein CCZ1 homolog. | Uncharacterized protein. | 0.739 |
CCZ1 | WDR81 | ENSGALP00000005469 | ENSGALP00000053129 | Vacuolar fusion protein CCZ1 homolog. | WD repeat domain 81. | 0.836 |
CCZ1 | WDR91 | ENSGALP00000005469 | ENSGALP00000019133 | Vacuolar fusion protein CCZ1 homolog. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.750 |
EPG5 | BECN1 | ENSGALP00000056736 | ENSGALP00000004697 | Uncharacterized protein. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.410 |
EPG5 | PLEKHM1 | ENSGALP00000056736 | ENSGALP00000065696 | Uncharacterized protein. | Uncharacterized protein. | 0.552 |
EPG5 | WDR91 | ENSGALP00000056736 | ENSGALP00000019133 | Uncharacterized protein. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.601 |
MFSD12 | WDR81 | ENSGALP00000001151 | ENSGALP00000053129 | Major facilitator superfamily domain containing 12. | WD repeat domain 81. | 0.750 |
MFSD12 | WDR91 | ENSGALP00000001151 | ENSGALP00000019133 | Major facilitator superfamily domain containing 12. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.783 |
NOP58 | WDR12 | ENSGALP00000013761 | ENSGALP00000013788 | NOP58 ribonucleoprotein. | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. | 0.976 |
NOP58 | WDR91 | ENSGALP00000013761 | ENSGALP00000019133 | NOP58 ribonucleoprotein. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. | 0.583 |
PLEKHM1 | BECN1 | ENSGALP00000065696 | ENSGALP00000004697 | Uncharacterized protein. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.417 |
PLEKHM1 | CCZ1 | ENSGALP00000065696 | ENSGALP00000005469 | Uncharacterized protein. | Vacuolar fusion protein CCZ1 homolog. | 0.739 |