STRINGSTRING
MGP MGP PROS1 PROS1 BGLAP BGLAP SPP1 SPP1 GAS6 GAS6 POSTN POSTN PDE6H PDE6H MFAP5 MFAP5 ASPN ASPN COL3A1 COL3A1 SPARC SPARC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa)    
Predicted Functional Partners:
PROS1
Protein S.
   
  
 0.801
BGLAP
Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
      
 0.793
SPP1
Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.
   
  
 0.775
GAS6
Growth arrest specific 6.
   
  
 0.724
POSTN
Uncharacterized protein.
   
  
 0.682
PDE6H
Phosphodiesterase 6 gamma subunit cone form.
      
 0.607
MFAP5
Microfibril associated protein 5.
   
  
 0.596
ASPN
Asporin.
   
  
 0.584
COL3A1
Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.
   
  
 0.579
SPARC
SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity).
   
  
 0.561
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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