STRINGSTRING
METTL14 METTL14 METTL3 METTL3 WTAP WTAP ALKBH5 ALKBH5 VIRMA VIRMA YTHDF1 YTHDF1 YTHDF2 YTHDF2 CBLL1 CBLL1 ZC3H13 ZC3H13 YTHDC2 YTHDC2 YTHDC1 YTHDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
METTL14N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. (459 aa)    
Predicted Functional Partners:
METTL3
Methyltransferase like 3; Belongs to the MT-A70-like family.
  
 
0.999
WTAP
WT1 associated protein.
   
 0.999
ALKBH5
2OG-FeII_Oxy_2 domain-containing protein.
   
  
 0.990
VIRMA
Vir like m6A methyltransferase associated.
    
 0.989
YTHDF1
YTH domain-containing protein.
  
   
 0.980
YTHDF2
YTH N6-methyladenosine RNA binding protein 2.
  
   
 0.975
CBLL1
E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing; Belongs to the Hakai family.
    
 0.955
ZC3H13
Zinc finger CCCH-type containing 13.
   
 
 0.946
YTHDC2
YTH domain containing 2.
   
 
 0.942
YTHDC1
YTH domain-containing protein.
   
 
 0.940
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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