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TDRD7 TDRD7 PIWIL1 PIWIL1 TDRD9 TDRD9 TDRD9-2 TDRD9-2 NANOS1 NANOS1 TDRD12 TDRD12 CRYBB3 CRYBB3 CRYAA CRYAA BFSP1 BFSP1 DND1 DND1 FYCO1 FYCO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TDRD7Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of specific genes in the developing lens. Also required during spermatogenesis. (1095 aa)    
Predicted Functional Partners:
PIWIL1
Piwi-like protein 1; Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived fro [...]
   
 
 0.834
TDRD9
Tudor domain containing 9.
   
 
 0.786
TDRD9-2
Uncharacterized protein.
   
 
 0.761
NANOS1
Nanos C2HC-type zinc finger 1; Belongs to the nanos family.
   
  
 0.732
TDRD12
CS domain-containing protein.
    
 
 0.710
CRYBB3
Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens.
      
 0.701
CRYAA
Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens; Belongs to the small heat shock protein (HSP20) family.
    
 
 0.682
BFSP1
Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments.
      
 0.672
DND1
DND microRNA-mediated repression inhibitor 1.
    
 
 0.613
FYCO1
Uncharacterized protein.
      
 0.601
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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