node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BAK1 | ENSGALP00000037437 | ENSGALP00000055311 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.817 |
APAF1 | BCL2 | ENSGALP00000037437 | ENSGALP00000020984 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). | 0.978 |
APAF1 | BCL2L11 | ENSGALP00000037437 | ENSGALP00000070659 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 like 11. | 0.640 |
APAF1 | BECN1 | ENSGALP00000037437 | ENSGALP00000004697 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.431 |
APAF1 | BID | ENSGALP00000037437 | ENSGALP00000048995 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). | 0.559 |
APAF1 | BMF | ENSGALP00000037437 | ENSGALP00000041985 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein. | 0.508 |
APAF1 | CASP3 | ENSGALP00000037437 | ENSGALP00000068843 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-3; Belongs to the peptidase C14A family. | 0.982 |
APAF1 | CASP9 | ENSGALP00000037437 | ENSGALP00000002083 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYCS | ENSGALP00000037437 | ENSGALP00000017934 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.999 |
BAK1 | APAF1 | ENSGALP00000055311 | ENSGALP00000037437 | Uncharacterized protein. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.817 |
BAK1 | BCL2 | ENSGALP00000055311 | ENSGALP00000020984 | Uncharacterized protein. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). | 0.985 |
BAK1 | BCL2L11 | ENSGALP00000055311 | ENSGALP00000070659 | Uncharacterized protein. | BCL2 like 11. | 0.916 |
BAK1 | BECN1 | ENSGALP00000055311 | ENSGALP00000004697 | Uncharacterized protein. | Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. | 0.681 |
BAK1 | BID | ENSGALP00000055311 | ENSGALP00000048995 | Uncharacterized protein. | BH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). | 0.995 |
BAK1 | BMF | ENSGALP00000055311 | ENSGALP00000041985 | Uncharacterized protein. | Uncharacterized protein. | 0.584 |
BAK1 | CASP3 | ENSGALP00000055311 | ENSGALP00000068843 | Uncharacterized protein. | Caspase-3; Belongs to the peptidase C14A family. | 0.751 |
BAK1 | CASP9 | ENSGALP00000055311 | ENSGALP00000002083 | Uncharacterized protein. | Caspase 9; Belongs to the peptidase C14A family. | 0.757 |
BAK1 | CYCS | ENSGALP00000055311 | ENSGALP00000017934 | Uncharacterized protein. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.965 |
BCL2 | APAF1 | ENSGALP00000020984 | ENSGALP00000037437 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.978 |
BCL2 | BAK1 | ENSGALP00000020984 | ENSGALP00000055311 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). | Uncharacterized protein. | 0.985 |