STRINGSTRING
MAEA MAEA ARMC8 ARMC8 ARMC7 ARMC7 RMND5A RMND5A WDR26 WDR26 YPEL5 YPEL5 GID8 GID8 ZNF385B ZNF385B C15H12orf49 C15H12orf49 MKLN1 MKLN1 ZMYND19 ZMYND19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MAEAE3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturati [...] (396 aa)    
Predicted Functional Partners:
ARMC8
Uncharacterized protein.
    
 0.879
ARMC7
Uncharacterized protein.
      
 0.870
RMND5A
Uncharacterized protein.
   
0.860
WDR26
WD repeat domain 26.
   
 0.838
YPEL5
Protein yippee-like; Belongs to the yippee family.
   
 
 0.791
GID8
Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation.
  
 
0.718
ZNF385B
Zinc finger protein 385B.
      
 0.705
C15H12orf49
UPF0454 protein C12orf49 homolog.
   
  
 0.652
MKLN1
Uncharacterized protein.
   
 
 0.639
ZMYND19
MIZIP protein.
      
 0.627
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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