STRINGSTRING
CNOT7 CNOT7 CNOT1 CNOT1 CNOT2 CNOT2 CNOT4 CNOT4 CNOT9 CNOT9 CNOT10 CNOT10 CNOT8 CNOT8 DCP2 DCP2 CNOT11 CNOT11 DDX6 DDX6 TOB2 TOB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CNOT7CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa)    
Predicted Functional Partners:
CNOT1
Uncharacterized protein.
   
 0.995
CNOT2
NOT2_3_5 domain-containing protein.
   
 0.987
CNOT4
Uncharacterized protein.
    
 0.984
CNOT9
Uncharacterized protein.
   
 0.981
CNOT10
CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).
   
 0.976
CNOT8
Uncharacterized protein.
  
 
0.969
DCP2
Decapping mRNA 2.
   
 
 0.958
CNOT11
CCR4-NOT transcription complex subunit 11.
   
 0.956
DDX6
Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
   
 
 0.954
TOB2
Uncharacterized protein.
    
 
 0.920
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.