node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHUK | IKBKB | ENSGALP00000051589 | ENSGALP00000051668 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Protein kinase domain-containing protein. | 0.998 |
CHUK | OPTN | ENSGALP00000051589 | ENSGALP00000022287 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | 0.726 |
CHUK | TBK1 | ENSGALP00000051589 | ENSGALP00000015982 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | Protein kinase domain-containing protein. | 0.704 |
GABARAPL1 | GABARAPL2 | ENSGALP00000023699 | ENSGALP00000005074 | GABA type A receptor associated protein like 1. | GABA type A receptor associated protein like 2. | 0.921 |
GABARAPL1 | OPTN | ENSGALP00000023699 | ENSGALP00000022287 | GABA type A receptor associated protein like 1. | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | 0.918 |
GABARAPL2 | GABARAPL1 | ENSGALP00000005074 | ENSGALP00000023699 | GABA type A receptor associated protein like 2. | GABA type A receptor associated protein like 1. | 0.921 |
GABARAPL2 | OPTN | ENSGALP00000005074 | ENSGALP00000022287 | GABA type A receptor associated protein like 2. | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | 0.917 |
IKBKB | CHUK | ENSGALP00000051668 | ENSGALP00000051589 | Protein kinase domain-containing protein. | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | 0.998 |
IKBKB | OPTN | ENSGALP00000051668 | ENSGALP00000022287 | Protein kinase domain-containing protein. | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | 0.726 |
OPTN | CHUK | ENSGALP00000022287 | ENSGALP00000051589 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. | 0.726 |
OPTN | GABARAPL1 | ENSGALP00000022287 | ENSGALP00000023699 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | GABA type A receptor associated protein like 1. | 0.918 |
OPTN | GABARAPL2 | ENSGALP00000022287 | ENSGALP00000005074 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | GABA type A receptor associated protein like 2. | 0.917 |
OPTN | IKBKB | ENSGALP00000022287 | ENSGALP00000051668 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Protein kinase domain-containing protein. | 0.726 |
OPTN | PLK1 | ENSGALP00000022287 | ENSGALP00000009850 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Serine/threonine-protein kinase PLK. | 0.750 |
OPTN | RAB8A | ENSGALP00000022287 | ENSGALP00000041790 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. | 0.739 |
OPTN | RBM12B | ENSGALP00000022287 | ENSGALP00000046557 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Uncharacterized protein. | 0.763 |
OPTN | SAXO2 | ENSGALP00000022287 | ENSGALP00000009860 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Stabilizer of axonemal microtubules 2. | 0.707 |
OPTN | TBC1D22A | ENSGALP00000022287 | ENSGALP00000066088 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Rab-GAP TBC domain-containing protein. | 0.770 |
OPTN | TBK1 | ENSGALP00000022287 | ENSGALP00000015982 | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | Protein kinase domain-containing protein. | 0.935 |
PLK1 | OPTN | ENSGALP00000009850 | ENSGALP00000022287 | Serine/threonine-protein kinase PLK. | Optineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. | 0.750 |