STRINGSTRING
OPTN OPTN TBK1 TBK1 GABARAPL1 GABARAPL1 GABARAPL2 GABARAPL2 TBC1D22A TBC1D22A RBM12B RBM12B PLK1 PLK1 RAB8A RAB8A CHUK CHUK IKBKB IKBKB SAXO2 SAXO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
OPTNOptineurin; Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. (557 aa)    
Predicted Functional Partners:
TBK1
Protein kinase domain-containing protein.
   
 0.935
GABARAPL1
GABA type A receptor associated protein like 1.
    
 0.918
GABARAPL2
GABA type A receptor associated protein like 2.
   
 0.917
TBC1D22A
Rab-GAP TBC domain-containing protein.
   
  
 0.770
RBM12B
Uncharacterized protein.
      
 0.763
PLK1
Serine/threonine-protein kinase PLK.
     
  0.750
RAB8A
Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family.
     
 0.739
CHUK
Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    
 
 0.726
IKBKB
Protein kinase domain-containing protein.
   
 
 0.726
SAXO2
Stabilizer of axonemal microtubules 2.
    
 
 0.707
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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