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ALDH1A1 ALDH1A1 CYP26A1 CYP26A1 RDH10 RDH10 CYP26B1 CYP26B1 ADH1C ADH1C RDH11 RDH11 DHRS3 DHRS3 ADH4 ADH4 ADH6 ADH6 BCO1 BCO1 SDR16C5 SDR16C5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa)    
Predicted Functional Partners:
CYP26A1
Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...]
   
 
 0.987
RDH10
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 0.987
CYP26B1
Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.
   
 
 0.979
ADH1C
Alcohol dehydrogenase 1.
 
 0.979
RDH11
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 0.962
DHRS3
Uncharacterized protein.
  
 0.962
ADH4
S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
 
 0.959
ADH6
PKS_ER domain-containing protein.
 
 0.959
BCO1
Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family.
   
 
 0.956
SDR16C5
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.948
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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