STRINGSTRING
ASCC3 ASCC3 ASCC2 ASCC2 TRIP4 TRIP4 PRPF3 PRPF3 ASCC1 ASCC1 CNTLN CNTLN PRPF8 PRPF8 NWD1 NWD1 DHX29 DHX29 SLC38A8 SLC38A8 TBC1D2 TBC1D2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ASCC3Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. (2211 aa)    
Predicted Functional Partners:
ASCC2
Activating signal cointegrator 1 complex subunit 2.
    
 
 0.966
TRIP4
Thyroid hormone receptor interactor 4.
    
 
 0.946
PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
    
 
 0.860
ASCC1
Activating signal cointegrator 1 complex subunit 1.
    
 
 0.848
CNTLN
Centlein.
      
 0.842
PRPF8
Pre-mRNA processing factor 8.
   
 
 0.800
NWD1
WD_REPEATS_REGION domain-containing protein.
   
 
 0.763
DHX29
ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.
    
 
 0.762
SLC38A8
Solute carrier family 38 member 8.
      
 0.756
TBC1D2
TBC1 domain family member 2.
      
 0.748
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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