node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ASPN | ENSGALP00000010867 | ENSGALP00000007507 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Asporin. | 0.900 |
ACAN | BCAN | ENSGALP00000010867 | ENSGALP00000061057 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Brevican. | 0.843 |
ACAN | CD44 | ENSGALP00000010867 | ENSGALP00000056897 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Link domain-containing protein. | 0.698 |
ACAN | COL3A1 | ENSGALP00000010867 | ENSGALP00000051057 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.990 |
ACAN | DCN | ENSGALP00000010867 | ENSGALP00000062069 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.931 |
ACAN | ELN | ENSGALP00000010867 | ENSGALP00000069288 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. | 0.725 |
ACAN | FN1 | ENSGALP00000010867 | ENSGALP00000005653 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). | 0.731 |
ACAN | NCAN | ENSGALP00000010867 | ENSGALP00000068929 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Uncharacterized protein. | 0.780 |
ACAN | TNN | ENSGALP00000010867 | ENSGALP00000069927 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Tenascin N. | 0.612 |
ACAN | VCAN | ENSGALP00000010867 | ENSGALP00000025144 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. | 0.863 |
ASPN | ACAN | ENSGALP00000007507 | ENSGALP00000010867 | Asporin. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.900 |
ASPN | BCAN | ENSGALP00000007507 | ENSGALP00000061057 | Asporin. | Brevican. | 0.714 |
ASPN | CD44 | ENSGALP00000007507 | ENSGALP00000056897 | Asporin. | Link domain-containing protein. | 0.442 |
ASPN | COL3A1 | ENSGALP00000007507 | ENSGALP00000051057 | Asporin. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. | 0.942 |
ASPN | DCN | ENSGALP00000007507 | ENSGALP00000062069 | Asporin. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.607 |
ASPN | ELN | ENSGALP00000007507 | ENSGALP00000069288 | Asporin. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. | 0.642 |
ASPN | FN1 | ENSGALP00000007507 | ENSGALP00000005653 | Asporin. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity). | 0.718 |
ASPN | VCAN | ENSGALP00000007507 | ENSGALP00000025144 | Asporin. | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. | 0.746 |
BCAN | ACAN | ENSGALP00000061057 | ENSGALP00000010867 | Brevican. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.843 |
BCAN | ASPN | ENSGALP00000061057 | ENSGALP00000007507 | Brevican. | Asporin. | 0.714 |