STRINGSTRING
CENPU CENPU CENPP CENPP CENPO CENPO CENPQ CENPQ CENPN CENPN ITGB3BP ITGB3BP CENPT CENPT CENPI CENPI CENPM CENPM CENPK CENPK CENPW CENPW
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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CENPUCentromere protein U; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation. (345 aa)    
Predicted Functional Partners:
CENPP
Centromere protein P; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
   
 0.999
CENPO
Centromere protein O; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Involved in kinetochore assembly and required for recovery from spindle damage; Belongs to the CENP-O/MCM21 family.
   
 0.999
CENPQ
Centromere protein Q; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May play an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. Belongs to the CENP-Q/OKP1 family.
   
 0.999
CENPN
Centromere protein N; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-N/CHL4 family.
   
 0.999
ITGB3BP
Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand- dependent fashion. Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity).
   
 0.999
CENPT
Centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...]
   
 0.999
CENPI
Centromere protein I; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
   
 0.999
CENPM
Centromere protein M; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
   
 0.998
CENPK
Centromere protein K; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
   
 0.998
CENPW
Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...]
   
 0.993
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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