STRINGSTRING
RNASE6 RNASE6 RNH1 RNH1 RSFR RSFR C1QA C1QA CATH3 CATH3 AvBD7 AvBD7 CATH1 CATH1 C1QB C1QB TGM3 TGM3 CL2 CL2 AvBD1 AvBD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
RNASE6Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity). (139 aa)    
Predicted Functional Partners:
RNH1
Uncharacterized protein.
   
   0.902
RSFR
Ribonuclease homolog.
  
 
0.620
C1QA
Complement C1q A chain.
   
    0.553
CATH3
Cathelicidin-3; May bind bacterial lipopolysaccharide (LPS). May have antimicrobial activity and play a role in the innate immune response (By similarity).
      
 0.537
AvBD7
Gallinacin-7; Has bactericidal activity.
   
  
 0.522
CATH1
Cathelicidin-1; Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response.
   
  
 0.512
C1QB
Complement C1q B chain.
   
    0.512
TGM3
TGc domain-containing protein.
      
 0.499
CL2
Ribonuclease CL2; Pyrimidine-specific nuclease with preference for C; Belongs to the pancreatic ribonuclease family.
  
 
0.478
AvBD1
Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans.
   
  
 0.474
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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