node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD31481.1 | ABD31482.1 | SAOUHSC_02461 | SAOUHSC_02462 | Transcriptional regulator, merR family, putative. | Hypothetical protein. | 0.459 |
ABD31481.1 | hysA | SAOUHSC_02461 | SAOUHSC_02463 | Transcriptional regulator, merR family, putative. | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | 0.459 |
ABD31482.1 | ABD31481.1 | SAOUHSC_02462 | SAOUHSC_02461 | Hypothetical protein. | Transcriptional regulator, merR family, putative. | 0.459 |
ABD31482.1 | hysA | SAOUHSC_02462 | SAOUHSC_02463 | Hypothetical protein. | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | 0.773 |
hlb | hysA | SAOUHSC_02240 | SAOUHSC_02463 | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | 0.457 |
hlb | icaA | SAOUHSC_02240 | SAOUHSC_03002 | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | Intercellular adhesion protein A, putative; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity (By similarity). | 0.413 |
hlb | spa | SAOUHSC_02240 | SAOUHSC_00069 | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...] | 0.411 |
hlb | sspA | SAOUHSC_02240 | SAOUHSC_00988 | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | Glutamyl endopeptidase precursor, putative; Preferentially cleaves peptide bonds on the carboxyl-terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobu [...] | 0.417 |
hysA | ABD31481.1 | SAOUHSC_02463 | SAOUHSC_02461 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Transcriptional regulator, merR family, putative. | 0.459 |
hysA | ABD31482.1 | SAOUHSC_02463 | SAOUHSC_02462 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Hypothetical protein. | 0.773 |
hysA | hlb | SAOUHSC_02463 | SAOUHSC_02240 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | 0.457 |
hysA | icaA | SAOUHSC_02463 | SAOUHSC_03002 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Intercellular adhesion protein A, putative; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity (By similarity). | 0.506 |
hysA | icaB | SAOUHSC_02463 | SAOUHSC_03004 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | icaB protein, putative; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions (By similarity). | 0.469 |
hysA | icaC | SAOUHSC_02463 | SAOUHSC_03005 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Intercellular adhesion protein C, putative; Presumably involved in the export of the biofilm adhesin polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA) across the cell membrane. | 0.441 |
hysA | sdrC | SAOUHSC_02463 | SAOUHSC_00544 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | sdrC protein, putative; Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis. Mediates interactions with components of the extracellular matrix such as host NRXN1 to promote bacterial adhesion. | 0.570 |
hysA | sdrD | SAOUHSC_02463 | SAOUHSC_00545 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | sdrD protein, putative; Cell surface-associated calcium-binding protein which plays an important role in adhesion and pathogenesis. Mediates interactions with components of the extracellular matrix such as host DSG1 to promote bacterial adhesion to host cells. Contributes to the resistance to killing by innate immune components such as neutrophils present in blood and thus attenuates bacterial clearance. | 0.444 |
hysA | spa | SAOUHSC_02463 | SAOUHSC_00069 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...] | 0.682 |
hysA | sspA | SAOUHSC_02463 | SAOUHSC_00988 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Glutamyl endopeptidase precursor, putative; Preferentially cleaves peptide bonds on the carboxyl-terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobu [...] | 0.451 |
icaA | hlb | SAOUHSC_03002 | SAOUHSC_02240 | Intercellular adhesion protein A, putative; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity (By similarity). | Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family. | 0.413 |
icaA | hysA | SAOUHSC_03002 | SAOUHSC_02463 | Intercellular adhesion protein A, putative; N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Requires IcaD for full activity (By similarity). | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | 0.506 |