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TPH2 TPH2 PCBD1 PCBD1 PCBD2 PCBD2 DDC DDC IDO2 IDO2 SPR SPR IDO1 IDO1 TPH1 TPH1 TDO2 TDO2 AKR1B10 AKR1B10 IL4I1 IL4I1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPH2Tryptophan 5-hydroxylase 2. (490 aa)    
Predicted Functional Partners:
PCBD1
Pterin-4-alpha-carbinolamine dehydratase.
  
 0.977
PCBD2
Pterin-4 alpha-carbinolamine dehydratase 2.
  
 0.977
DDC
Aromatic-L-amino-acid decarboxylase.
   
 0.958
IDO2
Indoleamine 2,3-dioxygenase 2.
   
 
 0.957
SPR
Sepiapterin reductase.
   
 
 0.949
IDO1
Indoleamine 2,3-dioxygenase 1.
   
 
 0.941
TPH1
Tryptophan hydroxylase 1.
  
 
0.925
TDO2
Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
  
 
 0.925
AKR1B10
Aldo-keto reductase family 1 member B10.
   
 
 0.906
IL4I1
Amine oxidase.
   
 
  0.903
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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