STRINGSTRING
RMI1 RMI1 TOP3A TOP3A RMI2 RMI2 BLM BLM FANCM FANCM RPA1 RPA1 RPA3 RPA3 RPA2 RPA2 FANCA FANCA FAAP100 FAAP100 ENSGGOP00000036407 ENSGGOP00000036407
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RMI1RecQ mediated genome instability 1. (625 aa)    
Predicted Functional Partners:
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.999
RMI2
RecQ mediated genome instability 2.
    
 0.999
BLM
BLM RecQ like helicase.
   
 0.999
FANCM
FA complementation group M.
    
 0.999
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.999
RPA3
Replication protein A3.
    
 0.999
RPA2
Replication protein A2.
   
 0.994
FANCA
FA complementation group A.
    
 
 0.989
FAAP100
FA core complex associated protein 100.
    
 
 0.989
ENSGGOP00000036407
Centromere protein X.
    
 
 0.988
Your Current Organism:
Gorilla gorilla
NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla
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