STRINGSTRING
NANOG NANOG SOX2 SOX2 SALL4 SALL4 KLF4 KLF4 STAT3 STAT3 POU5F1 POU5F1 PRDM14 PRDM14 DROSHA DROSHA CTNNB1 CTNNB1 ENSPTRP00000068971 ENSPTRP00000068971 ENSPTRP00000082402 ENSPTRP00000082402
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NANOGHomeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] (305 aa)    
Predicted Functional Partners:
SOX2
SRY-box transcription factor 2.
    
 0.996
SALL4
SALL4 isoform 1.
   
 0.993
KLF4
Kruppel-like factor 4 (Gut).
    
 0.984
STAT3
Signal transducer and activator of transcription.
     
 0.980
POU5F1
POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity).
   
 0.969
PRDM14
PR/SET domain 14.
    
 0.961
DROSHA
Drosha, ribonuclease type III.
     
 0.944
CTNNB1
Catenin (Cadherin-associated protein), beta 1, 88kDa.
    
 0.938
ENSPTRP00000068971
annotation not available
   
 0.927
ENSPTRP00000082402
annotation not available
   
 0.927
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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