STRINGSTRING
KRT17 KRT17 LOC738608 LOC738608 KRT5 KRT5 SFN SFN ENSPTRP00000087057 ENSPTRP00000087057 KRT16 KRT16 UNC79 UNC79 KRT14 KRT14 TXNDC9 TXNDC9 LOC101058414 LOC101058414 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
KRT17Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] (432 aa)    
Predicted Functional Partners:
LOC738608
KRT6B isoform 1; Belongs to the intermediate filament family.
   
0.848
KRT5
Keratin, type II cytoskeletal 5; Belongs to the intermediate filament family.
  
0.776
SFN
SFN isoform 1; Belongs to the 14-3-3 family.
   
 0.772
ENSPTRP00000087057
annotation not available
  
 
 
0.752
KRT16
KRT16 isoform 4; Belongs to the intermediate filament family.
  
 
 
0.751
UNC79
UNC79 isoform 1.
   
 0.680
KRT14
KRT14 isoform 1; Belongs to the intermediate filament family.
  
 
0.639
TXNDC9
Thioredoxin domain containing 9.
    
 
 0.596
LOC101058414
Thioredoxin domain-containing protein 9 pseudogene.
    
 
 0.596
EGFR
Receptor protein-tyrosine kinase.
    
 
 0.570
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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