STRINGSTRING
TGIF1 TGIF1 SMAD2 SMAD2 TGIF2 TGIF2 CTBP1 CTBP1 NR2C2 NR2C2 SMAD4 SMAD4 SMAD3 SMAD3 OSR1 OSR1 SKIL SKIL PCSK6 PCSK6 MRAS MRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TGIF1Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activitie [...] (401 aa)    
Predicted Functional Partners:
SMAD2
Mothers against decapentaplegic homolog.
    
 0.982
TGIF2
Homeobox protein TGIF2.
  
  
 
0.923
CTBP1
C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
    
 
 0.814
NR2C2
NR2C2 isoform 1.
   
 0.651
SMAD4
Mothers against decapentaplegic homolog.
    
 0.644
SMAD3
Mothers against decapentaplegic homolog.
    
 0.644
OSR1
Odd-skipped related transcription factor 1.
    
 
 0.614
SKIL
SKI like proto-oncogene.
      
 0.610
PCSK6
PCSK6 isoform 3; Belongs to the peptidase S8 family.
      
 0.582
MRAS
Muscle RAS oncogene homolog.
   
 
 0.566
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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