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ANXA1 ANXA1 S100A10 S100A10 DYSF DYSF FPR1 FPR1 TRIM72 TRIM72 ANXA2 ANXA2 CK820_G0008402 CK820_G0008402 CAV3 CAV3 ENSPTRP00000066121 ENSPTRP00000066121 ANXA6 ANXA6 FPR3 FPR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of Fthe formyl peptide receptors (By similarity). Contribu [...] (346 aa)    
Predicted Functional Partners:
S100A10
S100 calcium binding protein A10; Belongs to the S-100 family.
   
 0.980
DYSF
DYSF isoform 8.
   
 0.958
FPR1
fMet-Leu-Phe receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity).
    
 0.945
TRIM72
Tripartite motif containing 72.
    
 0.934
ANXA2
Annexin.
  
0.932
CK820_G0008402
Annexin.
  
0.931
CAV3
Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.
   
 
 0.925
ENSPTRP00000066121
annotation not available
  
0.921
ANXA6
Annexin.
  
0.889
FPR3
N-formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
    
 0.850
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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