node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACAD8 | ENSPPYP00000015674 | ENSPPYP00000004658 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | ACAD8 isoform 1. | 0.562 |
ACAA1 | ACADS | ENSPPYP00000015674 | ENSPPYP00000005742 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | 0.987 |
ACAA1 | ACADSB | ENSPPYP00000015674 | ENSPPYP00000003189 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). | 0.986 |
ACAA1 | ACAT1 | ENSPPYP00000015674 | ENSPPYP00000004400 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
ACAA1 | ACAT2 | ENSPPYP00000015674 | ENSPPYP00000019199 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.919 |
ACAA1 | ECHS1 | ENSPPYP00000015674 | ENSPPYP00000003261 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.888 |
ACAA1 | EHHADH | ENSPPYP00000015674 | ENSPPYP00000016064 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.993 |
ACAA1 | GCDH | ENSPPYP00000015674 | ENSPPYP00000010777 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | GCDH isoform 3. | 0.636 |
ACAA1 | HADHA | ENSPPYP00000015674 | ENSPPYP00000014051 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.985 |
ACAA1 | HADHB | ENSPPYP00000015674 | ENSPPYP00000014050 | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.934 |
ACAD8 | ACAA1 | ENSPPYP00000004658 | ENSPPYP00000015674 | ACAD8 isoform 1. | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.562 |
ACAD8 | ACADS | ENSPPYP00000004658 | ENSPPYP00000005742 | ACAD8 isoform 1. | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | 0.935 |
ACAD8 | ACADSB | ENSPPYP00000004658 | ENSPPYP00000003189 | ACAD8 isoform 1. | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). | 0.937 |
ACAD8 | ACAT1 | ENSPPYP00000004658 | ENSPPYP00000004400 | ACAD8 isoform 1. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.552 |
ACAD8 | ACAT2 | ENSPPYP00000004658 | ENSPPYP00000019199 | ACAD8 isoform 1. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.552 |
ACAD8 | ECHS1 | ENSPPYP00000004658 | ENSPPYP00000003261 | ACAD8 isoform 1. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.959 |
ACAD8 | EHHADH | ENSPPYP00000004658 | ENSPPYP00000016064 | ACAD8 isoform 1. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.960 |
ACAD8 | HADHA | ENSPPYP00000004658 | ENSPPYP00000014051 | ACAD8 isoform 1. | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.960 |
ACAD8 | HADHB | ENSPPYP00000004658 | ENSPPYP00000014050 | ACAD8 isoform 1. | HADHB isoform 3; Belongs to the thiolase-like superfamily. Thiolase family. | 0.655 |
ACADS | ACAA1 | ENSPPYP00000005742 | ENSPPYP00000015674 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] | Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.987 |