STRINGSTRING
NOX4 NOX4 CYBB CYBB ENSPPYP00000008618 ENSPPYP00000008618 NCF1 NCF1 NCF2 NCF2 NOX3 NOX3 NOX1 NOX1 NOX5 NOX5 NCF4 NCF4 DUOX1 DUOX1 TLR4 TLR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
NOX4NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). (578 aa)    
Predicted Functional Partners:
CYBB
Cytochrome b-245 beta chain.
  
 
0.998
ENSPPYP00000008618
annotation not available
   
 0.991
NCF1
NCF1 isoform 3.
   
 0.925
NCF2
NCF2 isoform 3.
   
 0.921
NOX3
NOX3 isoform 1.
  
 
0.897
NOX1
NOX1 isoform 2.
  
 
0.896
NOX5
NOX5 isoform 4.
     
0.866
NCF4
NCF4 isoform 3.
   
 0.851
DUOX1
DUOX1 isoform 1.
     
0.845
TLR4
TLR4 isoform 1; Belongs to the Toll-like receptor family.
   
 
 0.763
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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