STRINGSTRING
EPS8 EPS8 ABI1 ABI1 BAIAP2 BAIAP2 MYO15A MYO15A WHRN WHRN SOS1 SOS1 CASK CASK ESPN ESPN MPP1 MPP1 MYO3A MYO3A ESPNL ESPNL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)    
Predicted Functional Partners:
ABI1
Abl interactor 1.
   
 
 0.979
BAIAP2
BAI1 associated protein 2.
    
 
 0.973
MYO15A
MYO15A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.970
WHRN
WHRN isoform 2.
     
 0.963
SOS1
SOS1 isoform 2.
   
 
 0.962
CASK
CASK isoform 2; Belongs to the MAGUK family.
   
 0.959
ESPN
ESPN isoform 1.
     
 0.950
MPP1
55 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Belongs to the MAGUK family.
   
 0.930
MYO3A
MYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.929
ESPNL
ESPNL isoform 1.
     
 0.914
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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