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EIF6 EIF6 RPL23 RPL23 RPL18A RPL18A RPL24 RPL24 NMD3 NMD3 RPL14 RPL14 RPL38 RPL38 RPL8 RPL8 RPL35A RPL35A RPL11 RPL11 CR201_G0000560 CR201_G0000560
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)    
Predicted Functional Partners:
RPL23
60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.988
RPL18A
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
  
 
 0.986
RPL24
RPL24 isoform 2.
   
 
 0.983
NMD3
60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
   
 
 0.981
RPL14
RPL14 isoform 1.
  
 
 0.980
RPL38
Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family.
    
 
 0.979
RPL8
60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family.
  
 
 0.978
RPL35A
60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.
   
 
 0.976
RPL11
60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]
  
 
 0.974
CR201_G0000560
RPL34 isoform 1.
  
 
 0.974
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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