node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | BRAF | ENSPPYP00000022715 | ENSPPYP00000020265 | A-Raf proto-oncogene, serine/threonine kinase. | BRAF isoform 1. | 0.997 |
ARAF | RAF1 | ENSPPYP00000022715 | ENSPPYP00000014975 | A-Raf proto-oncogene, serine/threonine kinase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.990 |
ARAF | YWHAB | ENSPPYP00000022715 | ENSPPYP00000012330 | A-Raf proto-oncogene, serine/threonine kinase. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.961 |
ARAF | YWHAE | ENSPPYP00000022715 | ENSPPYP00000008753 | A-Raf proto-oncogene, serine/threonine kinase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.827 |
ARAF | YWHAQ | ENSPPYP00000022715 | ENSPPYP00000014137 | A-Raf proto-oncogene, serine/threonine kinase. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.930 |
ARAF | YWHAZ | ENSPPYP00000022715 | ENSPPYP00000021077 | A-Raf proto-oncogene, serine/threonine kinase. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. | 0.933 |
BAD | RAF1 | ENSPPYP00000003594 | ENSPPYP00000014975 | BCL2 associated agonist of cell death. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.986 |
BAD | YWHAB | ENSPPYP00000003594 | ENSPPYP00000012330 | BCL2 associated agonist of cell death. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.974 |
BAD | YWHAE | ENSPPYP00000003594 | ENSPPYP00000008753 | BCL2 associated agonist of cell death. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.981 |
BAD | YWHAQ | ENSPPYP00000003594 | ENSPPYP00000014137 | BCL2 associated agonist of cell death. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.989 |
BAD | YWHAZ | ENSPPYP00000003594 | ENSPPYP00000021077 | BCL2 associated agonist of cell death. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. | 0.981 |
BRAF | ARAF | ENSPPYP00000020265 | ENSPPYP00000022715 | BRAF isoform 1. | A-Raf proto-oncogene, serine/threonine kinase. | 0.997 |
BRAF | RAF1 | ENSPPYP00000020265 | ENSPPYP00000014975 | BRAF isoform 1. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.998 |
BRAF | YWHAB | ENSPPYP00000020265 | ENSPPYP00000012330 | BRAF isoform 1. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.996 |
BRAF | YWHAE | ENSPPYP00000020265 | ENSPPYP00000008753 | BRAF isoform 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.976 |
BRAF | YWHAQ | ENSPPYP00000020265 | ENSPPYP00000014137 | BRAF isoform 1. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.981 |
BRAF | YWHAZ | ENSPPYP00000020265 | ENSPPYP00000021077 | BRAF isoform 1. | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity); Belongs to the 14-3-3 family. | 0.973 |
FOXO3 | YWHAB | ENSPPYP00000018917 | ENSPPYP00000012330 | FOXO3 isoform 1. | 14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by [...] | 0.954 |
FOXO3 | YWHAE | ENSPPYP00000018917 | ENSPPYP00000008753 | FOXO3 isoform 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. | 0.957 |
FOXO3 | YWHAQ | ENSPPYP00000018917 | ENSPPYP00000014137 | FOXO3 isoform 1. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.951 |