node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSPPYP00000011940 | MRPL17 | ENSPPYP00000011940 | ENSPPYP00000004052 | annotation not available | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | 0.968 |
ENSPPYP00000011940 | RPL11 | ENSPPYP00000011940 | ENSPPYP00000002010 | annotation not available | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.968 |
ENSPPYP00000011940 | RPL23 | ENSPPYP00000011940 | ENSPPYP00000009553 | annotation not available | 60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. | 0.968 |
ENSPPYP00000011940 | RPS11 | ENSPPYP00000011940 | ENSPPYP00000023489 | annotation not available | RPS11 isoform 3; Belongs to the universal ribosomal protein uS17 family. | 0.986 |
ENSPPYP00000011940 | RPS3 | ENSPPYP00000011940 | ENSPPYP00000004215 | annotation not available | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.986 |
ENSPPYP00000011940 | SEC61A1 | ENSPPYP00000011940 | ENSPPYP00000015030 | annotation not available | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] | 0.921 |
ENSPPYP00000011940 | SEC61B | ENSPPYP00000011940 | ENSPPYP00000021785 | annotation not available | Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis (By similarity). | 0.564 |
ENSPPYP00000011940 | SEC61G | ENSPPYP00000011940 | ENSPPYP00000019673 | annotation not available | SEC61 translocon gamma subunit. | 0.509 |
MRPL17 | ENSPPYP00000011940 | ENSPPYP00000004052 | ENSPPYP00000011940 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | annotation not available | 0.968 |
MRPL17 | RPL11 | ENSPPYP00000004052 | ENSPPYP00000002010 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 0.994 |
MRPL17 | RPL23 | ENSPPYP00000004052 | ENSPPYP00000009553 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | 60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. | 0.994 |
MRPL17 | RPS11 | ENSPPYP00000004052 | ENSPPYP00000023489 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | RPS11 isoform 3; Belongs to the universal ribosomal protein uS17 family. | 0.994 |
MRPL17 | RPS3 | ENSPPYP00000004052 | ENSPPYP00000004215 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.994 |
MRPL17 | SEC61A1 | ENSPPYP00000004052 | ENSPPYP00000015030 | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] | 0.926 |
RPL11 | ENSPPYP00000011940 | ENSPPYP00000002010 | ENSPPYP00000011940 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | annotation not available | 0.968 |
RPL11 | MRPL17 | ENSPPYP00000002010 | ENSPPYP00000004052 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 39S ribosomal protein L17, mitochondrial; Belongs to the bacterial ribosomal protein bL17 family. | 0.994 |
RPL11 | RPL23 | ENSPPYP00000002010 | ENSPPYP00000009553 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 60S ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. | 0.999 |
RPL11 | RPN1 | ENSPPYP00000002010 | ENSPPYP00000015025 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] | 0.410 |
RPL11 | RPS11 | ENSPPYP00000002010 | ENSPPYP00000023489 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | RPS11 isoform 3; Belongs to the universal ribosomal protein uS17 family. | 0.996 |
RPL11 | RPS3 | ENSPPYP00000002010 | ENSPPYP00000004215 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] | 0.994 |