STRINGSTRING
GBA3 GBA3 GAA GAA SI SI NAGLU NAGLU NAT8 NAT8 FGF23 FGF23 FGF19 FGF19 GNPTAB GNPTAB FGF18 FGF18 STIL STIL RET RET
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GBA3Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] (469 aa)    
Predicted Functional Partners:
GAA
Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.
  
 0.914
SI
SI isoform 1.
  
 0.914
NAGLU
N-acetyl-alpha-glucosaminidase.
   
  
 0.684
NAT8
NAT8 isoform 1.
      
 0.683
FGF23
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.646
FGF19
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.627
GNPTAB
GNPTAB isoform 1.
      
 0.508
FGF18
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.479
STIL
STIL isoform 3.
   
 0.464
RET
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
   
 0.464
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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