node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FGF18 | FGF19 | ENSPPYP00000017950 | ENSPPYP00000003433 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.682 |
FGF18 | FGF23 | ENSPPYP00000017950 | ENSPPYP00000005881 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.829 |
FGF18 | GBA3 | ENSPPYP00000017950 | ENSPPYP00000016355 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | 0.479 |
FGF18 | RET | ENSPPYP00000017950 | ENSPPYP00000002579 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.533 |
FGF18 | STIL | ENSPPYP00000017950 | ENSPPYP00000001600 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | STIL isoform 3. | 0.528 |
FGF19 | FGF18 | ENSPPYP00000003433 | ENSPPYP00000017950 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.682 |
FGF19 | FGF23 | ENSPPYP00000003433 | ENSPPYP00000005881 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.667 |
FGF19 | GBA3 | ENSPPYP00000003433 | ENSPPYP00000016355 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | 0.627 |
FGF19 | RET | ENSPPYP00000003433 | ENSPPYP00000002579 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.517 |
FGF19 | STIL | ENSPPYP00000003433 | ENSPPYP00000001600 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | STIL isoform 3. | 0.514 |
FGF23 | FGF18 | ENSPPYP00000005881 | ENSPPYP00000017950 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.829 |
FGF23 | FGF19 | ENSPPYP00000005881 | ENSPPYP00000003433 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.667 |
FGF23 | GBA3 | ENSPPYP00000005881 | ENSPPYP00000016355 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | 0.646 |
FGF23 | RET | ENSPPYP00000005881 | ENSPPYP00000002579 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.559 |
FGF23 | STIL | ENSPPYP00000005881 | ENSPPYP00000001600 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | STIL isoform 3. | 0.559 |
GAA | GBA3 | ENSPPYP00000009778 | ENSPPYP00000016355 | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | 0.914 |
GAA | SI | ENSPPYP00000009778 | ENSPPYP00000015950 | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. | SI isoform 1. | 0.929 |
GBA3 | FGF18 | ENSPPYP00000016355 | ENSPPYP00000017950 | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.479 |
GBA3 | FGF19 | ENSPPYP00000016355 | ENSPPYP00000003433 | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.627 |
GBA3 | FGF23 | ENSPPYP00000016355 | ENSPPYP00000005881 | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones [...] | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.646 |