node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSMC2 | PSMC3 | ENSPPYP00000020045 | ENSPPYP00000003790 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.999 |
PSMC2 | PSMC4 | ENSPPYP00000020045 | ENSPPYP00000011174 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. | 0.999 |
PSMC2 | PSMC6 | ENSPPYP00000020045 | ENSPPYP00000006612 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. | 0.999 |
PSMC2 | PSMD11 | ENSPPYP00000020045 | ENSPPYP00000009176 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Proteasome 26S subunit, non-ATPase 11. | 0.997 |
PSMC2 | PSMD12 | ENSPPYP00000020045 | ENSPPYP00000009620 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. | 0.999 |
PSMC2 | PSMD13 | ENSPPYP00000020045 | ENSPPYP00000022356 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | PSMD13 isoform 6. | 0.997 |
PSMC2 | PSMD2 | ENSPPYP00000020045 | ENSPPYP00000016052 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. | 0.999 |
PSMC2 | PSMD6 | ENSPPYP00000020045 | ENSPPYP00000015370 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Proteasome 26S subunit, non-ATPase 6. | 0.999 |
PSMC2 | PSMD8 | ENSPPYP00000020045 | ENSPPYP00000011119 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. | 0.999 |
PSMC2 | UBLCP1 | ENSPPYP00000020045 | ENSPPYP00000017904 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity). | 0.944 |
PSMC3 | PSMC2 | ENSPPYP00000003790 | ENSPPYP00000020045 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] | 0.999 |
PSMC3 | PSMC4 | ENSPPYP00000003790 | ENSPPYP00000011174 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. | 0.999 |
PSMC3 | PSMC6 | ENSPPYP00000003790 | ENSPPYP00000006612 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. | 0.999 |
PSMC3 | PSMD11 | ENSPPYP00000003790 | ENSPPYP00000009176 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, non-ATPase 11. | 0.998 |
PSMC3 | PSMD12 | ENSPPYP00000003790 | ENSPPYP00000009620 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. | 0.999 |
PSMC3 | PSMD13 | ENSPPYP00000003790 | ENSPPYP00000022356 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | PSMD13 isoform 6. | 0.998 |
PSMC3 | PSMD2 | ENSPPYP00000003790 | ENSPPYP00000016052 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. | 0.999 |
PSMC3 | PSMD6 | ENSPPYP00000003790 | ENSPPYP00000015370 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, non-ATPase 6. | 0.999 |
PSMC3 | PSMD8 | ENSPPYP00000003790 | ENSPPYP00000011119 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. | 0.999 |
PSMC3 | UBLCP1 | ENSPPYP00000003790 | ENSPPYP00000017904 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity). | 0.934 |