STRINGSTRING
KRT23 KRT23 CDKN3 CDKN3 KRT40 KRT40 KRT16 KRT16 KRT39 KRT39 KRT25 KRT25 KRT15 KRT15 KRT33A KRT33A KRT26 KRT26 KRT31 KRT31 CDC26 CDC26
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRT23Keratin, type I cytoskeletal 23; Keratin 23. (422 aa)    
Predicted Functional Partners:
CDKN3
Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
      
 0.549
KRT40
Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family.
  
 
0.483
KRT16
Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance; Belongs to the intermediate filament family.
  
 
0.480
KRT39
Keratin, type I cytoskeletal 39; May play a role in late hair differentiation.
  
 
0.472
KRT25
Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization.
  
 
0.468
KRT15
Keratin, type I cytoskeletal 15; Keratin 15.
   
 
0.468
KRT33A
Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.
  
 
0.466
KRT26
Keratin, type I cytoskeletal 26; Keratin 26.
  
  
0.463
KRT31
Keratin, type I cuticular Ha1; Keratin 31.
  
 
0.462
CDC26
Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
      
 0.461
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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