STRING 10 
  CDKN1B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (198 aa)
(Homo sapiens)
Predicted Functional Partners:
CDK2
cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell [...] (298 aa)
     0.999
CDK4
cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosph [...] (303 aa)
     0.999
CCND1
cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhi [...] (295 aa)
     0.999
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase; Substrate recognition compone [...] (424 aa)
     0.999
CCNE1
cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa)
     0.999
CCND3
cyclin D3; Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhi [...] (292 aa)
     0.999
CDK6
cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell [...] (326 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
CCNA2
cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosi [...] (432 aa)
     0.999
AKT1
v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonin [...] (480 aa)
     0.999
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
 
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