RIPK1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF signaling. TNF stimulation induces binding of RIPK1-TRADD-TRAF2-TRAF5 complex to TNFR1. TRAF proteins then catalyze the 'Lys-63'-linked polyubiquitination of RIPK1, inducing RIPK1 association with the IKK complex, which is subsequently activated, leading ultimately to the activation of NF-kappa-B. The inflammatory response is kept transient by the action of the NF-kappa-B target gene product TNFAIP3. TNFAIP3 is recruited to RIPK1 within a complex comprising also RNF11, ITCH and TAX1BP1. TNFAIP3 [...] (671 aa)
(Homo sapiens)
Predicted Functional Partners:
caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation casca [...] (538 aa)
TNF receptor-associated factor 2; Adapter protein and signal transducer that links members of t [...] (501 aa)
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)
receptor-interacting serine-threonine kinase 3; Promotes apoptosis (518 aa)
baculoviral IAP repeat-containing 2; Apoptotic suppressor. The BIR motifs region interacts with [...] (618 aa)
ubiquitin C (685 aa)
CASP2 and RIPK1 domain containing adaptor with death domain; Apoptotic adaptor molecule specifi [...] (199 aa)
tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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