CBL protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...] (906 aa)
(Homo sapiens)
Predicted Functional Partners:
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
epidermal growth factor receptor (1210 aa)
sprouty homolog 2 (Drosophila); May function as an antagonist of fibroblast growth factor (FGF) [...] (315 aa)
vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation o [...] (845 aa)
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosin [...] (536 aa)
SHC (Src homology 2 domain containing) transforming protein 1 (584 aa)
v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their b [...] (304 aa)
v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intrace [...] (303 aa)
zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role [...] (619 aa)
FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role i [...] (537 aa)
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