STRING 9.1 
  CBL protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CBL
Cas-Br-M (murine) ecotropic retroviral transforming sequence; Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling (906 aa)
(Homo sapiens)
Predicted Functional Partners:
SPRY2
sprouty homolog 2 (Drosophila); May function as an antagonist of fibroblast growth factor (FGF) [...] (315 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
     0.999
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
     0.999
SYK
spleen tyrosine kinase; Positive effector of BCR-stimulated responses. Couples the B-cell antig [...] (635 aa)
     0.999
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
     0.999
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
     0.999
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intrace [...] (303 aa)
     0.999
CRK
v-crk sarcoma virus CT10 oncogene homolog (avian); The Crk-I and Crk-II forms differ in their b [...] (304 aa)
     0.999
SH3KBP1
SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal tran [...] (665 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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