node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHRNA3 | CHRNA5 | ENSP00000315602 | ENSP00000299565 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.980 |
CHRNA3 | FAM13A | ENSP00000315602 | ENSP00000264344 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.720 |
CHRNA3 | GSTCD | ENSP00000315602 | ENSP00000422354 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.445 |
CHRNA3 | HHIP | ENSP00000315602 | ENSP00000296575 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.665 |
CHRNA3 | IREB2 | ENSP00000315602 | ENSP00000258886 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.696 |
CHRNA3 | RIN3 | ENSP00000315602 | ENSP00000216487 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. | 0.418 |
CHRNA5 | CHRNA3 | ENSP00000299565 | ENSP00000315602 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.980 |
CHRNA5 | FAM13A | ENSP00000299565 | ENSP00000264344 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.641 |
CHRNA5 | GSTCD | ENSP00000299565 | ENSP00000422354 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.437 |
CHRNA5 | HHIP | ENSP00000299565 | ENSP00000296575 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.582 |
CHRNA5 | IREB2 | ENSP00000299565 | ENSP00000258886 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.671 |
CHRNA5 | RIN3 | ENSP00000299565 | ENSP00000216487 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. | 0.410 |
FAM13A | CHRNA3 | ENSP00000264344 | ENSP00000315602 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.720 |
FAM13A | CHRNA5 | ENSP00000264344 | ENSP00000299565 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | 0.641 |
FAM13A | GSTCD | ENSP00000264344 | ENSP00000422354 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. | 0.708 |
FAM13A | HHIP | ENSP00000264344 | ENSP00000296575 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP family. | 0.854 |
FAM13A | IREB2 | ENSP00000264344 | ENSP00000258886 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | 0.869 |
FAM13A | MMP12 | ENSP00000264344 | ENSP00000458585 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3; Belongs to the peptidase M10A family. | 0.626 |
FAM13A | RIN3 | ENSP00000264344 | ENSP00000216487 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family. | 0.623 |
FAM13A | SERPINA1 | ENSP00000264344 | ENSP00000416066 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family. | 0.615 |