node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PDCD7 | RNPC3 | ENSP00000204549 | ENSP00000432886 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | 0.845 |
PDCD7 | SF3B1 | ENSP00000204549 | ENSP00000335321 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.741 |
PDCD7 | SF3B2 | ENSP00000204549 | ENSP00000318861 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.730 |
PDCD7 | SF3B6 | ENSP00000204549 | ENSP00000233468 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch si [...] | 0.720 |
PDCD7 | SNRNP25 | ENSP00000204549 | ENSP00000372482 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Small nuclear ribonucleoprotein U11/U12 subunit 25. | 0.921 |
PDCD7 | SNRNP35 | ENSP00000204549 | ENSP00000403310 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Small nuclear ribonucleoprotein U11/U12 subunit 35. | 0.988 |
PDCD7 | SNRNP48 | ENSP00000204549 | ENSP00000339834 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5' splice site recognition. | 0.938 |
PDCD7 | YBX1 | ENSP00000204549 | ENSP00000361626 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA st [...] | 0.801 |
PDCD7 | ZCRB1 | ENSP00000204549 | ENSP00000266529 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Zinc finger CCHC-type and RNA binding motif containing 1. | 0.913 |
PDCD7 | ZMAT5 | ENSP00000204549 | ENSP00000344241 | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | Zinc finger matrin-type 5. | 0.954 |
RNPC3 | PDCD7 | ENSP00000432886 | ENSP00000204549 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Programmed cell death protein 7; Promotes apoptosis when overexpressed. | 0.845 |
RNPC3 | SF3B1 | ENSP00000432886 | ENSP00000335321 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved [...] | 0.976 |
RNPC3 | SF3B2 | ENSP00000432886 | ENSP00000318861 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. | 0.981 |
RNPC3 | SF3B6 | ENSP00000432886 | ENSP00000233468 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch si [...] | 0.964 |
RNPC3 | SNRNP25 | ENSP00000432886 | ENSP00000372482 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Small nuclear ribonucleoprotein U11/U12 subunit 25. | 0.891 |
RNPC3 | SNRNP35 | ENSP00000432886 | ENSP00000403310 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Small nuclear ribonucleoprotein U11/U12 subunit 35. | 0.984 |
RNPC3 | SNRNP48 | ENSP00000432886 | ENSP00000339834 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5' splice site recognition. | 0.958 |
RNPC3 | YBX1 | ENSP00000432886 | ENSP00000361626 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA st [...] | 0.903 |
RNPC3 | ZCRB1 | ENSP00000432886 | ENSP00000266529 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Zinc finger CCHC-type and RNA binding motif containing 1. | 0.975 |
RNPC3 | ZMAT5 | ENSP00000432886 | ENSP00000344241 | RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'- stem-loop of m(7)G-capped U12 snRNA. | Zinc finger matrin-type 5. | 0.988 |